| 
<<Previous Page Next Page>>
Free Content
|
F:
F:
The fraction of a dose which is absorbed and enters the systemic circulation following administration of a drug by any route other than the intravenous route; the availability of drug to tissues of the body, generally. When the total clearance and the dose of drug administered are known, F can be determined from the relationship: (AUC x ClT)/D = F. When identical doses of a drug have been given by the intravenous and by some other route (x), and the AUCs have been determined, the bioavailability of the drug after administration by route X can be determined: F=AUCx/AUCiv. The amount of free drug recovered in the urine (AU) after administration of identical doses given intravenously and by route X can also be used to determine bioavailability: F=AU,x/AU,iv
Cf. Bioavailability, First Pass Effect, AUC
free web content
Index:
A
B
C
D
E
F
G
H
I
K
M
N
N
P
P
R
S
T
V
Z
|
|
