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f:
f:
The fraction of C0 remaining at some specified time after drug administration; more generally, the fraction of C, or AB, remaining after some specified time interval. For first-order, single compartment systems (i.e. those yielding a single straight line when log C is plotted against t), f can be determined from the relationship: log C = log C0 - b t. When t is the time after drug administration, or the interval between two administrations, and t½ is the elimination half-life of the drug, f is 0.5 raised to a power that is the ratio of the time interval to the elimination half-life, i.e., 0.5t/t½.
Cf. Half-Life, Cmax, Css, Multiple Dose Regiment, Infusion Kinetics, Compartment, First-Order Kinetics
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