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ED50
ED50
1. In a quantal assay, the median effective dose.
2. In a graded (non-quantal) assay, the dose of a drug that produces 50% of the maximal response to that drug. It is preferable, where possible, to express potency in terms of EC50 but ED50 is appropriate for in vivo measurements and for those in vitro experiments where the absolute concentration is uncertain. If the maximum response is unknown, it is acceptable to express the effectiveness of a drug in terms of the dose that produces a particular level of response, for example a certain change in blood pressure or heart rate. In such a case, the appropriate units must be included (e.g. ED20mm) to avoid confusion.
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