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C0:
C0:
The fictive concentration of a drug or chemical in the plasma at the time (in theory) of an instantaneous intravenous injection of a drug that is instantaneously distributed to its volume of distribution. C0 is determined by extrapolating, to zero-time, the plot of log C against t (for apparently "first-order " decline of C) or of C against t (for apparently "zero-order" decline of C).
Cf. Volume of Distribution, Cmax, Css, First-Order Kinetics, Zero-Order Kinetics
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