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Vd:
Vd:
The volume of distribution of a drug; the size of the "compartment" into which a drug apparently has been distributed following absorption. Computed as D/C0 for a one-compartment system, i.e. one yielding a single straight line when log C, or C, is plotted against time after drug administration. Using absolute dose to compute Vd yields Vd in units of volume, i.e. liters. Using relative dose (D/B) to compute Vd yields Vd in relative units, e.g. liters per kilogram, the volume of distribution as a fraction of body weight. When the plot of log C against t yields a biphasic relationship (a two compartment system), Vd is computed by a different method, such as one based on the area under the C vs. t curve.
Cf. Volume of Distribution, Compartment
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