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Toxic Effects:
Toxic Effects:
Responses to drug that are harmful to the health or life of the individual. Almost by definition, toxic effects are "side effects" when diagnosis, prevention, or treatment of disease is the goal of drug administration. Toxic effects are not side-effects in the case of pesticides and chemical warfare agents. Toxic effects may be idiosyncratic or allergic in nature, may be pharmacologic side effects, or may be an extension of therapeutic effect produced by overdosage. An example of the last of these is the apnea produced by an anesthetic agent.
Cf. Idiosyncratic Response, Side Effects, Allergic Response, Therapeutic Index, Standardized Safety Margin, Clinical Therapeutic Index
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