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Spare Receptors:
Spare Receptors:
A pharmacological system has spare receptors (a receptor reserve), if an agonist can induce a maximum response when occupying less than 100% of the available receptors. The existence of spare receptors reflects a circumstance in which the maximum effect produced by an agonist is limited by some factor other than the number of activated receptors. Whether or not a system has spare receptors depends upon the nature of the receptor and its coupling to the measured response, the number of receptors, and the intrinsic activity of the agonist.
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